Integrative Molecular and Biomedical Sciences Ph.D. Program

Research Interests: Neuronal calcium signaling and neurodegeneration; molecular mechanisms of Huntington’s and Alzheimer’s disease; calcium channels; synaptic transmission

Research Interests: Tumor microenvironment, epithelial plasticity, immune therapy, angiogenesis, metastasis, ECM signaling, matricellular proteins

Research Interests: Unraveling the mechanism by which the SREBP pathway regulates cholesterol metabolism at the molecular, cellular, and whole-body levels

Research Interests: DNA damage response; repair of DNA double-strand breaks

Research Interests: Cell physiology; regulation of growth and atrophy; protein degradation; intracellular proteases; ubiquitin/proteasome pathway of protein degradation

Research Interests: Functional neuroanatomy of the mammalian hypothalamus

Research Interests: Mechanisms of neurodegeneration in neurological and psychiatric disorders, using human post-mortem tissue and animal models

Research Interests: Mechanisms of neurodegeneration in neurological and psychiatric disorders, using human post-mortem tissue and animal models

Research Interests: Molecular signaling processes in cardiac hypertrophy and failure; mechanisms of structural, functional, and electrophysiological remodeling, using genetic and surgical mice models

Research Interests: Molecular signaling processes in cardiac hypertrophy and failure; mechanisms of structural, functional, and electrophysiological remodeling, using genetic and surgical mice models

Research Interests: Cellular signaling, gene regulation, and epigenetic control in the chromatin environment of the nucleus. Biological systems include: reproduction, cancer, inflammation, adipogenesis, stem cells, differentiation

Research Interests: Neural control of energy metabolism, cellular and functional diversity in the hypothalamus

Research Interests: Synonymous codons as new genetic codes to regulate protein structure and gene expression, mechanism of circadian clocks, small and long coding RNAs

Research Interests: Mechanism of action of nuclear hormone receptors; transcriptional regulation of lipid metabolism; role of retinoids and cancer

Research Interests: Epigenetic mechanisms underlying cancer progression; ETS gene fusions in prostate cancer; genomic rearrangements in cancer; transcriptional regulation in prostate cancer

Research Interests: Molecular mechanisms in tissue-specific, developmental, and hormonal regulation of eukaryotic gene expression

Research Interests: Molecular basis of pathogenesis of antiphospholipid syndrome; role of Pentraxin C Reactive protein in metabolic syndrome; biology of lipoproteins and their receptors

Research Interests: Translational research; immune responses in autoimmune disease; the role of the immune system in neurological diseases of the brain

Research Interests: Cardiac development; transcriptional regulation; human genetics; arrhythmogenesis. The cardiac conduction system is an electrically coupled structure within the heart responsible for initiation and propagation of each heartbeat. Our lab is interested in elucidating the transcriptional mechanisms that dictate formation of the cardiac conduction system and its impact on the establishment of normal and pathological cardiac rhythms.

Research Interests: G protein-coupled receptors; Type 2 diabetes; insulin resistance; chronic inflammation; development of novel therapeutic targets to treat Type 2 diabetes

Research Interests: Transcriptional control of cell differentiation; muscle development

Research Interests: Size-control mechanisms in development, regeneration, and cancer

Research Interests: Adipocytes, angiogenesis, beta cells, breast cancer, intracellular protein trafficking

Research Interests: Endothelial cell biology, vascular development and disease; signaling molecules in endothelial cell caveolae/lipid rafts

Research Interests: Cellular metabolism, mitochondria, reproduction, cellular quiescence

Research Interests: Tissue interactions, inflammation, metabolism, benign prostatic hyperplasia, stem cells, prostate cancer

Research Interests: Metabolic cycles; mechanisms by which fundamental processes (e.g., cell growth and division, transcription, mitochondria homeostasis) are coupled to cellular metabolic state; yeast

Research Interests: Regulation of glucose uptake; autophagy and skin cancer

Research Interests: Understanding the cellular mechanisms that contribute to the coordinated control of food intake, body weight, and glucose homeostasis

Research Interests: Statistical methods in biomedical research, bioinformatics and computer software development, computer algorithm and database

Research Interests: Host proteins required for hepatitis C virus replication; regulation of geranylgeranyl lipid homeostasis; regulated intramembrane proteolysis

Research Interests: Actin cytoskeletons of nonmuscle cells, including reorganization in response to extracellular signals; structure/function relationships of the gelsolin family of actin regulatory proteins

Research Interests: Mechanisms by which the cell fates of adult stem cells are regulated, and the interaction of adult stem cells and their in vivo microenvironment; ex vivo expansion of HSCs for cell therapy and gene therapy; the interplay between stem cells and cancer

Research Interests: Identification of CNS targets of ghrelin action, the study of ghrelin cell physiology, functional neuroanatomy of the mammalian hypothalamus