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Neuroscience Course Descriptions

Helpful Documents: Degree Plan | Professional Outcomes

Required Courses

Core Curriculum – Proteins
Fall (1st half)
2 credit hours
Instruction includes the energetic basis of protein structure; stability; ligand binding and regulation; enzyme mechanics and kinetics; methods of purification; and analysis by spectroscopic methods.

Core Curriculum – Genes
Fall (1st half)
2 credit hours
Instruction includes molecular genetics of model organisms; DNA replication, repair and recombination; transcription; RNA catalysis, processing and interference; translation; protein turnover; developmental biology; and genomics.

Core Curriculum – Cells 
Fall (Full)
2 credit hours
Instruction includes cell structure; membrane biology; intracellular membrane and protein trafficking; energy conversion; signal transduction and second messengers; cytoskeleton; cell cycle; and introductory material in microbiology, immunology, and neurobiology.
 
Fundamentals of Neuroscience I 
Spring (1st half)
2.5 credit hours 
This course provides a foundation in the genetic, cellular, and synaptic bases of brain development, organization, and function. It combines integrated lectures, journal discussions, and experimental design.
 
Fundamentals of Neuroscience II 
Spring (2nd half)
2.5 credit hours
This course builds on the foundation established in Neuroscience Fundamentals I, focusing on large-scale networks and systems-level neuroscience. As in Neuroscience Fundamentals I, it combines integrated lectures, journal discussions, and experimental design. 
 
Research and Grant Writing Principles 
Summer (Full)
1 credit hour 
This course focuses on the logic of experimental design and the development of scientific communication skills, with particular emphasis on writing skills. Students design, compose, and present their own research proposals.
 

Professionalism, Responsible Conduct of Research, and Ethics I
Fall (Full)
1 credit hour
Topics covered through lectures and small group discussions: goals of education in RCR; professionalism; collaboration; teambuilding and professional behaviors; everyday practice of ethical science; mentorship; data management and reproducibility; animal research; genetics and human research.

Professionalism, Responsible Conduct of Research, and Ethics II
Spring (Full)
1 credit hour
Topics covered through lectures and small group discussions: codes of ethics and misconduct; building interprofessional teams; conflict of interest; sexual boundaries and professional behavior; applications of genetic testing; technology transfer and intellectual property; plagiarism, authorship, and citation; peer review; image and data manipulation.

Introduction to Biostatistics and Bioinformatics
Fall (Full)
2 credit hours 
Intro to Biostatistics introduces the fundamental principles of statistics and the appropriate use and interpretation of statistics. The course provides in-depth discussions of statistical concepts, probability distributions, and statistical tests. The course also covers aspects of experimental design to optimize the power of statistical analyses. Problem sets are designed to deepen the understanding of the taught material and to showcase applications to biomedical research cases.

Electives

Please review the degree plan (page 2) for specific elective requirements.

Neurobiology of Mental Illness
Spring (1st half on even years)
1.5 credit hours
The goal of this course is to provide an understanding of the neurobiology of psychiatric disorders. This course will highlight recent developments in depression, schizophrenia, and other related psychiatric illnesses, and emphasize the importance of translational research to better understand these diseases.

Neural Control of Homeostasis
Spring (2nd half on even years)
1.5 credit hours
The hypothalamus is one of the most essential and evolutionarily conserved regions of the mammalian brain. It lies at the base of the brain and is remarkably small, being approximately 4-5 grams of the total ~1,400 grams of the adult human brain weight. Absence of the hypothalamus is not compatible with life. In this course, we will explore the long array of diverse homeostatic processes that the hypothalamus governs. We will focus on hypothalamic-mediated control of body weight, glucose, and temperature homeostasis, as well as sleep/awake cycle and reproductive functions. Experts on the various topics will present lectures, followed by student presentations of relevant literature.

Heritable Neurological Diseases of Mice and Men
Spring (1st half on odd years)
1.5 credit hours
Many diseases of the mammalian nervous system are the result of mutations in single or multiple genes. In this course, we will explore the major inherited neurological disorders involving sensory, motor, and higher integrative systems. Our primary focus will be diseases of humans, but we will also consider insights gained in mouse, fly, and worm model systems. This course will have a molecular orientation, with the goal of correlating the neurological phenotypes with the functions of the affected proteins. Experts on the various topics will present lectures, followed by student presentations of relevant literature.

Synapses and Channels
Fall (1st half on even years)
1.5 credit hours
This course will explore the physiology and molecular architecture of chemical synapses. It will begin with an overview of synaptic anatomy and physiology before moving into details of how voltage gated channels bring the signal to the synapse and trigger vesicle fusion and neurotransmitter release. It will then jump across the synapse to the ionotropic and metabotropic receptors that transmit the chemical signal across the postsynaptic membrane and the scaffolds that localize them. The course will end with termination of signaling by endocytosis and the action of transporters.

Neurotechniques
Spring (1st half on odd years)
1.5 credit hours
This class will cover the major neuroscience research technologies and focus on cutting-edge methods. The technologies to be discussed include the following major aspects: 1) the methods of elucidating the structure of the brain at genetics, molecular, and cellular levels; 2) the methods of recording activities in the brain; and 3) functional control and manipulation of brain activities.

Current Topics in Neuroimaging
Fall (full semester)
3.0 credit hours 
This course provides an intensive lecture series on cutting-edge neuroimaging technologies, with a specific focus on magnetic resonance imaging (MRI) and other advanced imaging modalities developed and utilized by research groups at UT Southwestern. The first half of the semester will cover the fundamentals and advancements in MRI technology for brain research. The second half of the course will delve into Electroencephalogram (EEG), Magnetoencephalography (MEG), Positron emission tomography (PET), Near Infrared Spectroscopy (NIRS), and super high-resolution optical imaging technologies. Each module includes a background lecture and an in-depth exploration of the imaging modality's current state and applications in neuroscience

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